Cerebral Amyloid Quantification in Cognitively Normal Korean Adults Using F-18 Florbetaben PET / 대한핵의학회잡지
Korean Journal of Nuclear Medicine
; : 334-339, 2019.
Article
en En
| WPRIM
| ID: wpr-786490
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE: To investigate regional cerebral amyloid beta retention in cognitively normal Korean adults using F-18 florbetaben (FBB).METHODS: We prospectively analyzed F-18 FBB positron emission tomography (PET)/CT scans of 30 cognitively healthy adults (age range, 50??0 years) using automated quantification. The standardized uptake value ratios (SUVRs) of F-18 FBB were calculated for predefined regions by normalizing the regional count with cerebellar cortex.RESULTS: The distribution of amyloid beta for each brain region revealed no age-related trends (p > 0.05). From all subjects, mean SUVR of amyloid deposit was 1.30 ± 0.18. The right parietal lobe showed the highest SUVR value (1.46 ± 0.23), whereas the right frontal lobe and left precuneus showed the lowest SUVR (1.23 ± 0.25).CONCLUSIONS: We provide reference values of normative data obtained from healthy elderly Koreans and suggest its use for accurate diagnosis of patients with Alzheimer's disease.
Palabras clave
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1
Índice:
WPRIM
Asunto principal:
Lóbulo Parietal
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Valores de Referencia
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Encéfalo
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Corteza Cerebelosa
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Estudios Prospectivos
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Placa Amiloide
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Tomografía de Emisión de Positrones
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Diagnóstico
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Enfermedad de Alzheimer
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Lóbulo Frontal
Tipo de estudio:
Diagnostic_studies
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Observational_studies
Límite:
Adult
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Aged
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Humans
Idioma:
En
Revista:
Korean Journal of Nuclear Medicine
Año:
2019
Tipo del documento:
Article