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Effect of Amyloid Deposition in PET on Hippocampal Metabolism in Amnestic-Mild Cognitive Impairment : Pilot Study / 생물치료정신의학
Journal of the Korean Society of Biological Therapies in Psychiatry ; (3): 251-256, 2019.
Artículo en Coreano | WPRIM | ID: wpr-787411
ABSTRACT

OBJECTIVES:

Most studies of hippocampal metabolism(HM) in amnestic mild cognitive impairment(aMCI) gave inconsistent results. Our objective was to evaluate the effect of amyloid-beta(Aβ) status on hippocampal metabolism in aMCI.

METHODS:

Overall, 23 aMCI underwent three-dimensional magnetic resonance imaging(MRI), ¹⁸F-fluorodeoxyglucose-positron emission tomography(¹⁸FDG-PET) and ¹⁸F-Fluorbetaben amyloid positron emission tomography (amyloid-PET). According to Aβ status on amyloid PET, 23 aMCI were classified as either Aβ+aMCI(N=13) or Aβ−aMCI(N=10). The primary outcome was HM using ¹⁸FDG-PET and we investigate the difference on HM between Aβ+aMCI and Aβ−aMCI using analysis of variance(ANOVA) model, after controlling hippocampal volume.

RESULTS:

We found that HM was more decreased in Aβ+aMCI than Aβ−aMCI. This result was not changed after controlling hippocampal volume.

CONCLUSION:

Our findings suggest that Aβ+ is associated with decreased HM, regardless of hippocampal volume, in aMCI.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Proyectos Piloto / Trastornos del Conocimiento / Placa Amiloide / Tomografía de Emisión de Positrones / Amiloide / Metabolismo Tipo de estudio: Estudio pronóstico Idioma: Coreano Revista: Journal of the Korean Society of Biological Therapies in Psychiatry Año: 2019 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Proyectos Piloto / Trastornos del Conocimiento / Placa Amiloide / Tomografía de Emisión de Positrones / Amiloide / Metabolismo Tipo de estudio: Estudio pronóstico Idioma: Coreano Revista: Journal of the Korean Society of Biological Therapies in Psychiatry Año: 2019 Tipo del documento: Artículo