Lymph node micrometastasis in stage I and II rectal cancer
Korean Journal of Clinical Oncology
;
(2): 110-114, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-787989
ABSTRACT
PURPOSE:
The aim of this study was to determine the rate of lymph node (LN) micrometastasis in patients with stage I and II rectal cancer.METHODS:
One hundred eighty patients with either stage I or II rectal carcinoma who underwent curative resection between 1995 and 2010 were included. Forty-eight patients received neoadjuvant chemoradiotherapy. Two sections from each LN were stained with hematoxylin and eosin (H&E) and with CK20 by immunohistochemistry (IHC), respectively.RESULTS:
A total of 2,257 LNs with a median of 12.5 LNs per patient were examined. For IHC staining, CK20-positive neoplastic cells were found in 4 of the 2,257 LNs (0.2%) from 3 of the 180 patients (1.7%), and all corresponding H&E re-stained sections confirmed that these neoplastic cells were present. Three of four neoplastic cells were micrometastasis, and one was macrometastasis. All occult neoplastic cells were found in 3 of the 85 patients (3.5%) with stage II disease.CONCLUSION:
We observed a 3.5% rate of occult neoplastic cells in stage II rectal cancer. Interestingly, the results of IHC staining corresponded with those of H&E re-stained sections, suggesting that the examination of H&E stained section by a competent pathologist may replace IHC staining.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Neoplasias del Recto
/
Inmunohistoquímica
/
Eosina Amarillenta-(YS)
/
Micrometástasis de Neoplasia
/
Quimioradioterapia
/
Hematoxilina
/
Ganglios Linfáticos
/
Metástasis Linfática
Límite:
Humanos
Idioma:
Inglés
Revista:
Korean Journal of Clinical Oncology
Año:
2016
Tipo del documento:
Artículo
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