Role of Recepteur D'origine Nantais on Gastric Cancer Development and Progression / 전남의대학술지
Chonnam Medical Journal
;
: 178-186, 2017.
Artículo
en Inglés
| WPRIM
| ID: wpr-788391
ABSTRACT
Recepteur d'origine nantais (RON) is a receptor tyrosine kinase belonging to the subfamily of which c-MET is the prototype. Large epidemiologic studies have confirmed the strong association between RON and gastric cancer development. Constitutive activation of RON signaling directly correlates with tumorigenic phenotypes of gastric cancer and a poor survival rate in advanced gastric cancer patients. In this review, we focus on recent evidence of the aberrant expression and activation of RON in gastric cancer tumors and provide insights into the mechanism of RON signaling associated with gastric cancer progression and metastasis. Current therapeutics against RON in gastric cancer are summarized.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fenotipo
/
Neoplasias Gástricas
/
Proteínas Tirosina Quinasas
/
Estudios Epidemiológicos
/
Tasa de Supervivencia
/
Proteínas Proto-Oncogénicas c-met
/
Metástasis de la Neoplasia
Tipo de estudio:
Estudio observacional
Límite:
Humanos
Idioma:
Inglés
Revista:
Chonnam Medical Journal
Año:
2017
Tipo del documento:
Artículo
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