Two Cases of Multiple Endocrine Neoplasia Type II with RET Mutaion / 임상소아혈액종양
Clinical Pediatric Hematology-Oncology
;
: 163-167, 2014.
Artículo
en Coreano
| WPRIM
| ID: wpr-788513
ABSTRACT
Multiple endocrine neoplasia type 2(MEN2) is a rare autosomal dominant inherited disorder characterized by the presence of medullary thyroid carcinoma, pheochromocytoma and other hyperplasia and/or neoplasia of different endocrine tissues in a single patient. MEN 2 is caused by germline mutations in the RET proto-oncogene is located on the pericentromeric region of chromosome 10 (10q11.2). We present our experience with two rare cases of MEN 2, an 11-years-old girl and a 10-years-old boy. Their parents had medullary thyroid carcinoma and genetic analysis showed the missense mutation of RET. They were screened for mutations in the RET proto-oncogene and RET mutations were found at codons 634 and 641. They were asymptomatic state but the girl had prophylactic total thyroidectomy. Children of families with RET mutations may develop early cancers and require prophylactic thyroidectomy before eight years.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Padres
/
Feocromocitoma
/
Tiroidectomía
/
Cromosomas Humanos Par 10
/
Proto-Oncogenes
/
Codón
/
Neoplasia Endocrina Múltiple
/
Neoplasias de la Tiroides
/
Mutación de Línea Germinal
/
Neoplasia Endocrina Múltiple Tipo 2a
Límite:
Niño
/
Femenino
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Clinical Pediatric Hematology-Oncology
Año:
2014
Tipo del documento:
Artículo
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