A Case of Thrombotic Microangiopathy Following Autologous Stem Cell Transplantation / 임상소아혈액종양
Clinical Pediatric Hematology-Oncology
;
: 140-144, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-788518
ABSTRACT
Transplantation-associated thrombotic microangiopathy (TA-TMA) is an uncommon but devastating complication in patients who undergo hematopoietic stem cell transplantation (SCT). However, the optimal treatment strategy for TA-TMA is unclear. We report a rare case of TA-TMA in a 39-month-old boy who underwent tandem autologous SCT (autoSCT) for high-risk medulloblastoma. TA-TMA developed 64 days after the second autoSCT with microangiopathic hemolytic anemia, fever, renal impairment, acute respiratory distress syndrome and posterior reversible encephalopathy syndrome. The patient recovered after plasmapheresis and methylprednisolone therapy. He had mild to moderate deficiency of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS-13). The patient's clinical course would suggest that plasmapheresis and methylprednisolone therapy could be a treatment option for TA-TMA. Early intervention is needed to aid the recovery of the patient who is suspected for TA-TMA.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pediatría
/
Síndrome de Dificultad Respiratoria
/
Metilprednisolona
/
Plasmaféresis
/
Trasplante de Células Madre Hematopoyéticas
/
Intervención Educativa Precoz
/
Trombospondinas
/
Trasplante de Células Madre
/
Síndrome de Leucoencefalopatía Posterior
/
Microangiopatías Trombóticas
Límite:
Child, preschool
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Clinical Pediatric Hematology-Oncology
Año:
2014
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS