Role of hypoxia-inducible factor-1a in ischemia/reperfusion injury of donor kidney during kidney transplantation / 国际外科学杂志
International Journal of Surgery
;
(12): 634-639, 2019.
Artículo
en Chino
| WPRIM
| ID: wpr-789128
ABSTRACT
In the process of kidney acquisition and transplantation,the donor kidney undergoes hypoxia,ischemia and reperfusion,which inevitably leads to ischemia/reperfusion (I/R) injury of the donor kidney.Hypoxia-inducible factor-1α (HIF-1α) is a ubiquitous oxygen-sensitive transcription factor.It can be activated rapidly during I/R injury.Then preventing and reducing the I/R injury of donor kidney during kidney transplantation by mediating the adaptation of donor kidney to hypoxic stress through direct or indirect ways,and participating in the repair of injury,thereby improving the effect of kidney transplantation.This review describes the evidence of the role of HIF-1α in I/R injury of donor kidney during kidney transplantation,and provides a theoretical basis for further research.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
International Journal of Surgery
Año:
2019
Tipo del documento:
Artículo
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