Serum levels of omentin in chronic hemodialysis patients and its related factors / 上海预防医学

ABSTRACT

Objective] To investigate plasma level of omentin in chronic hemodialysis patients and its correlation with BMI,serum creatinine,fasting glucose,blood lipid and Homa-IR. [Methods] The study included 80 health people as control group and 62 chronic hemodialysis patients .A double antibody sandwich enzyme-linked immuno sorbent assay ( ELISA ) method was applied to detect the level of serum omentin and homeostasis model assessment of insulin resistant ( Homa-IR) to assess the insulin resistance index ,analysis being done on correlation between serum omentin and other indexes . [ Results ] The levels of plasma omentin was significantly higher in hemodialysis patients than those in control group ( P<0.01).ESRD(end-stage renal disease) patients with diabetes had lower level of plasma omentin than those without diabetes .The serum level of omentin had negative correlation with BMI and Homa-IR, and positive correlation with HDL-C, serum creatinine . [ Conclusion] The serum level of omentin proves to be ele-vated in ESRD patients receiving hemodialysis;and those with diabetes had lower levels of plasma omentin than those without .