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Predictive Factors for Radiation Pneumonitis in Lung Cancer Treated with Helical Tomotherapy / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment ; : 295-302, 2013.
Artículo en Inglés | WPRIM | ID: wpr-78972
ABSTRACT

PURPOSE:

Predictive factors for radiation pneumonitis (RP) after helical tomotherapy (HT) may differ from those after linac-based radiotherapy. In this study, we identified predictive factors for RP in patients with lung cancer treated with HT. MATERIALS AND

METHODS:

We retrospectively analyzed clinical, treatment-related and dosimetric factors from 31 patients with lung cancer treated with HT. RP was graded according to Common Terminology Criteria for Adverse Events version 4.0 and grade > or =2 RP was defined as a RP event. We used Kaplan-Meier methods to compute the actuarial incidence of RP. For univariate and multivariate analysis, the log-rank test and the Cox proportional regression hazard model were used. We generated receiver-operating characteristics (ROC) curves to define the cutoff values for significant parameters.

RESULTS:

The median follow-up duration was 6.6 months (range, 1.6 to 38.5 months). The 2-, 4-, and 6-month actuarial RP event rates were 13.2%, 58.5%, and 67.0%, respectively. There was no grade 4 or more RP. Ipsilateral V5, V10, V15, and contralateral V5 were related with RP event on univariate analysis. By multivariate analysis, ipsilateral V10 was factor most strongly associated with RP event. On the ROC curve, the cutoff values of ipsilateral V5, V10, V15, and contralateral V5 were 67.5%, 58.5%, 50.0%, and 55.5%, respectively.

CONCLUSION:

In our study, ipsilateral V5, V10, V15, and contralateral V5 were significant predictive factors for RP after HT.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Radioterapia / Modelos de Riesgos Proporcionales / Incidencia / Análisis Multivariante / Estudios Retrospectivos / Factores de Riesgo / Curva ROC / Estudios de Seguimiento / Neumonitis por Radiación / Radioterapia de Intensidad Modulada Tipo de estudio: Estudio de etiología / Estudio de incidencia / Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Humanos Idioma: Inglés Revista: Cancer Research and Treatment Año: 2013 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Radioterapia / Modelos de Riesgos Proporcionales / Incidencia / Análisis Multivariante / Estudios Retrospectivos / Factores de Riesgo / Curva ROC / Estudios de Seguimiento / Neumonitis por Radiación / Radioterapia de Intensidad Modulada Tipo de estudio: Estudio de etiología / Estudio de incidencia / Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Humanos Idioma: Inglés Revista: Cancer Research and Treatment Año: 2013 Tipo del documento: Artículo