Effect of Atorvastatin-Eluting Stents in a Rabbit Iliac Artery Restenosis Model / 전남의대학술지
Chonnam Medical Journal
;
: 118-124, 2013.
Artículo
en Inglés
| WPRIM
| ID: wpr-78981
ABSTRACT
Statins have pleiotropic effects, which include the inhibition of neointima hyperplasia, the inhibition of vascular inflammation, and platelet inhibition. The aim of this study was to examine the effect of an atorvastatin-eluting stent (AES) in a rabbit iliac artery overstretch restenosis model. Ten rabbits were used in this study (10 rabbits, 10 iliac arteries for each stent). An AES and paclitaxel-eluting stent (PES) were implanted in the left and right iliac arteries in a rabbit (2 stents in each rabbit). The stents were deployed with oversizing (stent/artery ratio 1.31), and histopathologic analysis was assessed at 28 days after stenting. There were no significant differences in the injury score, lumen area, or inflammation score. There were significant differences in the neointimal area (0.7+/-0.18 mm2 in the AES group vs. 0.4+/-0.25 mm2 in the PES group, p<0.01), in the percentage stenosis area (14.8+/-5.06% in the AES group vs. 10.5+/-6.80% in the PES group, p<0.05), and in the fibrin score (0.4+/-0.51 in the AES group vs. 2.7+/-0.48 in the PES group, p<0.001). Although the AES did not suppress neointimal hyperplasia compared with the PES, it showed a superior arterial healing effect in a rabbit iliac artery overstretch restenosis model.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Plaquetas
/
Fibrina
/
Stents
/
Constricción Patológica
/
Inhibidores de Hidroximetilglutaril-CoA Reductasas
/
Reestenosis Coronaria
/
Stents Liberadores de Fármacos
/
Neointima
/
Hiperplasia
/
Arteria Ilíaca
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Inglés
Revista:
Chonnam Medical Journal
Año:
2013
Tipo del documento:
Artículo
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