Evaluation value of the MRI parameter and immunohistochemistry in the neoadj uvant chemotherapy for HER-2 positive breast cancer / 实用放射学杂志

ABSTRACT

Objective To explore the evaluation value of MRI parameters and immunohistochemistry in the neoadjuvant chemotherapy (NAC)for the HER-2 positive breast cancer.Methods 7 6 patients with locally advanced HER-2 positive breast cancer were analyzed retrospectively.According to the postoperative pathology,patients were divided into pathological complete response (PCR)group and non-PCR (Non-PCR)group.First,univariate and multivariate Logistic regression analysis were used to analyze the predictors of PCR,and then we assessed the evaluation value of the assessment model which was built on multivariate logistic regression.Results Univariate regression analysis showed that menstrual status,ER expression,K-i 67 expression,ADC value,tumor diameter, ΔADC%(NAC2－NAC0),ΔD%(NAC0－NAC2) had predictive value for PCR;the parameters ΔADC% and ΔD%,the expression of ER and K-i 67 were independent predictors of PCR based on multivariate Logistic regression analysis.The AUC of the assessment model model was 0.873.Conclusion Based on the heterogeneity of breast cancer,combine MRI with immunohistochemistry parameters could improve the prediction in the middle of NAC,and provide imaging basis for the adj ustment of follow-up chemotherapy regimen.