Influence of different doses of atorvastatin short‐term treatment on serum levels of APN , hsCRP , GMP‐140 ,blood lipid metabolism and cardiac function indexes in CHD +T2DM patients / 心血管康复医学杂志

ABSTRACT

Objective:To explore influence of different doses of atorvastatin short‐term treatment on serum levels of adiponectin (APN) ,hsCRP ,thrombolytic granule membrane protein (GMP‐140) ,blood lipid metabolism and cardi‐ac function in patients with coronary heart disease (CHD) complicated type 2 diabetes mellitus (T2DM).Methods:A total of 108 CHD + T2DM patients treated in our hospital from May 2016 to May 2017 were randomly and equal‐ly divided into atorvastatin small dose group (10mg／d) and large dose group (40mg／d) ,each group received routine treatment simultaneously for 12 weeks .Levels of fasting plasma glucose (FPG) ,fasting insulin (FINS) ,homeostasis model‐insulin resistance index (HOMA‐IR) ,serum levels of APN ,GMP‐140 ,hsCRP etc .were measured and com‐pared between two groups before and after treatment .Results:Compared with small dose group after treatment , there were significant reductions in levels of FINS [ (7.83 ± 1.25) μIU／ml vs .(6. 95 ± 1.06) μIU／ml] ,HOMA‐IR [ (2.15 ± 0.68) vs.(1. 78 ± 0.55)] ,serum GMP‐140 [ (17. 24 ± 5.63) μg／L vs.(13. 35 ± 4.29) μg／L] ,hsCRP [ (4.83 ± 1.59) mg／L vs.(3. 56 ± 1. 17) mg／L] ,TC [ (4.83 ± 0.72) mmol／L vs.(4.11 ± 0.63) mmol／L] ,TG [ (1. 75 ± 0.46) mmol／L vs.(1.38 ± 0.35) mmol／L] ,LDL‐C [ (2.95 ± 0. 57) mmol／L vs.(2.47 ± 0.45) mmol／L] and LVEDd [ (46. 05 ± 6. 13) mm vs.(41. 59 ± 5. 28) mm] ,and significant rise in serum APN level [ (6. 40 ± 1.08) mg／L vs.(7. 22 ± 1.35) mg／L] ,LVEF [ (48.35 ± 6.08)% vs.(52.69 ± 7.53)%] and E／A [ (0. 93 ± 0. 16) vs.(1. 02 ± 0.19)] in large dose group , P＜0.01 all.Conclusion:Short‐term atorvastatin treatment can significantly improve HOMA‐IR and cardiac function ,regulate levels of blood lipid ,APN ,GMP‐140 and inflammatory factors in CHD + T2DM patients ,and it′s dose‐dependent .