Therapeutic effect of rosuvastatin on patients with coronary heart disease complicated hypertension and its impact on blood lipids / 心血管康复医学杂志

ABSTRACT

Objective :To observe therapeutic effect of rosuvastatin on patients with coronary heart disease (CHD ) complicated hypertension (EH) and its impact on blood lipids etc .Methods :A total of 112 CHD + EH patients treated in our hospital were randomly and equally divided into routine treatment group and rosuvastatin group .After three‐month treatment ,therapeutic effect was assessed ,levels of blood lipids ,blood pressure and incidence rate of adverse reactions were compared between two groups before and after treatment .Results :Total effective rate of ro‐suvastatin group was significantly higher than that of routine treatment group (92.86% vs.78. 57%, P＝ 0.031 ). After three‐month treatment ,compared with routine treatment group ,there were significant reductions in serum levels of TC [ (4.18 ± 0.96) mmol／Lvs.(3.21 ± 0. 87) mmol／L] ,TG [ (1. 68 ± 0.54) mmol／Lvs.(1. 31 ± 0. 51) mmol／L] , LDL‐C [ (2. 06 ± 0. 81 ) mmol／Lvs.(1.64 ± 0. 76 ) mmol／L ] , blood pressure [ (140. 77 ± 10.36 )／(82.94 ± 8.87) mmHgvs.(124.23 ± 9.48)／(72.49 ± 7.56 ) mmHg] and arterial plaque score [ (4.36 ± 0.71 ) scores vs .(4. 08 ± 0. 67 ) scores ] , and significant rise in HDL level [ (1.36 ± 0. 41 ) mmol／Lvs.(1. 68 ± 0.49 ) mmol／L] and fore brachial artery endothelium dependent diastolic‐systolic function (FMD) [ (7.36 ± 0. 98)% vs. (8. 59 ± 1. 06)%] in rosuvastatin group , P＜0. 05 or ＜0. 01 .There was no significant difference in incidence rate of adverse reactions between two groups , P＝ 0.487 .Conclusion : Rosuvastatin possesses significant therapeutic effect on CHD + EH .It can significantly improve levels of blood lipids and blood pressure and arterial function in these patients .