Therapeutic effect of Danshen dripping pills combined nicorandil on CHD patients with angina pectoris after PCI / 心血管康复医学杂志

ABSTRACT

Objective:To study therapeutic effect of compound Danshen dripping pills (CSDP) combined nicorandil on patients with coronary heart disease (CHD) and angina pectoris after percutaneous coronary intervention (PAP). Methods:A total of 176 PAP patients treated in our hospital from Jan 2014 to Dec 2017 were randomly and equally divided into nicorandil group and combined treatment group (received nicorandil + CSDP) ,each group received routine treatment simultaneously for eight weeks .Each dimension score and total score of Seattle angina question‐naire (SAQ) ,serum levels of hsCRP ,interleukin (IL)‐6 ,tumor necrosis factor (TNF)‐α ,heart type fatty acid binding protein (H‐FABP) ,creatine kinase isoenzyme MB (CK‐MB) ,cardiac troponin I (cTnI) ,endothelin (ET)‐1 ,nitric oxide (NO) and NO synthase (NOS) were observed and compared between two groups before and after treatment .Results:Compared with nicorandil group after treatment ,there were significant rise in each dimension score and total score [ (79. 90 ± 8.17) scores vs .(95.13 ± 9. 74) scores] of SAQ , serum levels of NO [ (62.54 ± 6.30) pg／ml vs.(82.41 ± 8.24) pg／ml] , NOS [ (24.13 ± 2.58) U／ml vs .(30.19 ± 3.11) U／ml] , significant re‐ductions in serum levels of hsCRP [ (5.96 ± 0.62) mg／L vs.(3.68 ± 0.37) mg／L] ,IL‐6 [ (25.89 ± 2.61) ng／L vs. (20.89 ± 2.18) ng／L] ,TNF‐α [ (10. 01 ± 1. 13) pg／ml vs .(6. 97 ± 0.73) pg／ml] ,H‐FABP [ (1.01 ± 0.10) ng／ml vs.(0.89 ± 0. 09) ng／ml] ,CK‐MB [ (14. 08 ± 1.42) U／L vs.(11.54 ± 1. 17) U／L] ,cTnI [ (0.26 ± 0.03) ng／ml vs.(0.22 ± 0.02) ng／ml] ,ET‐1 [ (70.76 ± 7.19) pg／ml vs.(52.96 ± 5.33) pg／ml] in combined treatment group , P＝0. 001 all.Conclusion:Compound Danshen dripping pills combined nicorandil can significantly reduce inflamma‐tory factor levels ,protect myocardial cells ,reduce myocardial injury and relieve angina pectoris symptoms in PAP patients .