Orthogonal design optimization in synthesis of novel triazole antifungal com-pounds as key intermediates / 药学实践杂志
Journal of Pharmaceutical Practice
; (6): 171-173, 2016.
Article
en Zh
| WPRIM
| ID: wpr-790583
Biblioteca responsable:
WPRO
ABSTRACT
Objective To optimize novel triazole antifungal compounds synthesis of key intermediates.Methods The or-thogonal experimental design is used,emphasizing on four factors including the reaction temperature,the weight ratio of mate-rial,reaction time and solvent on the yield.Results The effect of reaction temperature on the reaction yield is the most signifi-cant,followed by reaction time ;the weight ratio of material and solvent on the yield impact is not obvious.Conclusion The new technology has several advantages and yields up to about 50%,less reactive impurities,easy post processing.
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WPRIM
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Zh
Revista:
Journal of Pharmaceutical Practice
Año:
2016
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Article