Progress in molecular studies of Ph-positive and Ph-like acute lymphoblastic leukemia / 中国医师杂志

ABSTRACT

Acute lymphoblastic leukemia (ALL) is a highly heterogeneous disease.The prognosis of adolescents and adults with ALL is worse than that of children with ALL,mainly because of differences in biological characteristics.Molecular markers are of great value on risk stratification,prognosis evaluation,treatment guidance.The good news is with the deepening of studies on pathogenesis of ALL and the introduction of new technologies,novel molecular markers of prognostic relevance continue to be discovered.It was found that increased Sox4 expression was shown to correlate with accelerate leukemia progression.Unfortunately,resistance to medicine is associated with two cyclin-dependent kinase-inhibitor-2AB (CDKN2A/B) deletion.And the deletion of IKZF1 increase risk of relapse.Meanwhile,Ph-like acute lymphoblastic leukemia is characterized by a variety of genetic alterations that activate kinase or cytokine receptor signaling pathway.Identification of these molecular markers will provide important insights into the treatment strategies.This paper reviewed the advance in the Ph-positive ALL and Ph-like ALL.