Related factors for early neurological improvement after intravenous thrombolysis with alteplase in elderly patients with acute ischemic stroke / 中华老年医学杂志

ABSTRACT

Objective To analyze related factors for early neurological improvement after intravenous thrombolysis with alteplase in elderly patients with acute ischemic stroke (AIS).Methods Clinical data of elderly AIS patients with intravenous thrombolytic therapy within 4.5 hours of symptom onset were retrospectively analyzed.The demographic and clonical data were compared between improvement group and non-improvement group.Relevant factors for early neurological improvement after thrombolysis with a[teplase were analyzed by using multivariate logistic regression model.Results A total of 118 patients were included,of which 43 had early symptom improvement (36.44％).Multivariate logistic regression analysis showed that baseline NIHSS score(OR =1.098,95％CI=1.002-1.202,P=0.045),admission blood glucose(OR =1.377,95％CI=1.040-1.822,P =0.025),atrial fibrillation(OR =0.329,95 ％ CI =0.122-0.883,P =0.027) were significantly correlated with early symptom improvement after thrombolysis.Conclusions Baseline NIHSS score,admission blood glucose and atrial fibrillation are correlated with early neurological improvement after intravenous thrombolysis with alteptase in elderly AIS patients.