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Underlying Hemato-oncologic, Gastrointestinal-nutritional Diseases, or Prematurity May Be Risk Factors for Hypovitaminosi D in Children / 계명의대학술지
Keimyung Medical Journal ; : 89-97, 2015.
Artículo en Inglés | WPRIM | ID: wpr-79183
ABSTRACT

PURPOSE:

An adequate vitamin D level is important for normal growth, cancer prevention, controlling hormones, and immune regulation. However, no study has investigated vitamin D status in patients with serious illnesses, such as malignancies, malabsorption diseases, or prematurity in Korean children. Thus, we analyzed the results of 25-hydroxyvitamin D3 (25-D) levels in children in a single tertiary medical center.

METHODS:

Children who had their vitamin D level evaluated at Keimyung University Dongsan Medical Center from January 2004 to December 2014 were included. We reviewed the medical records and laboratory test results.

RESULTS:

Ninety-three children (malefemale = 4845) who had their vitamin D levels measured were included. The most common reason for measuring vitamin D level was hypocalcemia with or without neurological signs. Among the subjects, 61 children had hypovitaminosis D (25-D < 30 ng/mL). A positive correlation was detected between 25-D and total calcium levels (p = 0.001). Negative correlations were found between 25-D and immunoreactive parathyroid hormone (iPTH) levels (p = 0.002) and between 25-D and alkaline phosphatase (ALP) levels (p = 0.021). Twenty-three subjects (37.7%) had a critical underlying condition, including a hemato-oncologic issue (18.0%), gastrointestinal or nutritional problem (11.5%), and prematurity or low birth weight (8.2%).

CONCLUSION:

The levels of total calcium, ALP, and iPTH were correlated with 25-D level. An underlying malignancy, malabsorption issues, or prematurity may be risk factors for hypovitaminosis D in children.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Hormona Paratiroidea / Vitamina D / Calcifediol / Recién Nacido de Bajo Peso / Registros Médicos / Calcio / Factores de Riesgo / Fosfatasa Alcalina / Hipocalcemia Tipo de estudio: Estudio de etiología / Factores de riesgo Límite: Niño / Humanos / Recién Nacido Idioma: Inglés Revista: Keimyung Medical Journal Año: 2015 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Hormona Paratiroidea / Vitamina D / Calcifediol / Recién Nacido de Bajo Peso / Registros Médicos / Calcio / Factores de Riesgo / Fosfatasa Alcalina / Hipocalcemia Tipo de estudio: Estudio de etiología / Factores de riesgo Límite: Niño / Humanos / Recién Nacido Idioma: Inglés Revista: Keimyung Medical Journal Año: 2015 Tipo del documento: Artículo