A study on the influence of maternal history of allergy on the levels of cytokine in umbilical cord blood / 预防医学

ABSTRACT

Objective To explore the effect of maternal history of allergy on the cytokine level in umbilical cord blood. Methods A prospective study was conducted among pregnant women in Yiwu City,China.136 participants were selected from the Yiwu maternal and child healthcare hospital in 2012.A questionnaire interview was conducted.The umbilical cord blood sample were collected to detect the level of IgE,eosinophile granulocyte,eotaxin,IL -9,IL -6,IL -4,IL -5, IFN -γ,IL -10.The association between allergy history and cytokine levels was analyzed.Results All subjects were recruited and divided into two groups(pregnant women with allergy history and without allergy history).Compared with the pregnant women with allergy history,these subjects without allergy history had higher IL -13 (5.52 pg/ml vs 2.84 pg/ml) and IL4 (43.33 pg/ml vs 8.23 pg/ml)(P <0.05).Besides,there is a correlation between IL -13 and IL -4 (rs =0.87,P <0.01).Partial correlation analysis showed the correlaiots among IL -4,IL -5,IL -9,IL -10,IFN -γand eotaxin.Conclusion The levels of IL -13 and IL -4 are significantly associated with the history of allergy in pregnant women.It could be considered the indexes are sensitive for early screening and surveillance of allergy for babies.