A case -control study on the risk factors of congenital heart disease among perinatal infants / 预防医学

ABSTRACT

Objective To investigate the incidence of congenital heart disease (CHD)among perinatal infants in Hangzhou City and to explore risk factors of congenital heart disease in order to provide suggestions for CHD's prevention.Methods A hospital -based case -control study was carried out.Cases and controls were interviewed.By means of univariate and multiple logistic regression analysis,risk factors were analyzed.Results The incidence of CHD from 2009 to 2013 was 62.73 per 10,000.Of 176 perinatal infants with CHD,109 were single deformity and 67 were composite deformities of heart.The logistic regression analysis showed that maternal contact with harmful drugs during early pregnancy (OR =3.350,95%CI =1.024 -13.992),maternal respiratory infection during early pregnancy (OR =4.235,95%CI =1.275-18.735),abnormal childbearing history (OR =3.679,95%CI =1.102 -14.113),maternal smoking (OR =4.229, 95%CI =1.167 -15.782)and elderly parturient women (OR =2.974,95%CI =1.213 -16.372)were the risk factors of CHD.And maternal folic acid supplementation (OR =0.275,95% CI =0.079 -0.982 )was the protective factor. Conclusion It's of great importance to avoid risk factors and supply folic acid properly during pregnancy to prevent CHD.