The Role of CD4(+)CD25(bright) Regulatory T Cells in the Maintenance of Pregnancy, Premature Rupture of Membranes, and Labor
Yonsei Medical Journal
; : 366-371, 2008.
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| ID: wpr-79518
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ABSTRACT
PURPOSE: The aim of this study was to evaluate the changes of the regulatory T cell subset in peripheral blood caused by gestational age and premature rupture of membranes (PROM) with or without labor to verify the role of regulatory T cells in pregnancy. PATIENTS AND METHODS: We investigated regulatory T cell distribution in the peripheral blood of pregnancies during the first trimester (group I, n=2), the second trimester (group II, n=12), and the third trimester without PROM and labor (group III, n=15). In addition, we evaluated pregnancies in the third trimester complicated by PROM (group IV, n=4) and labor with no complication by PROM (Group V, n=5). Comparisons were made with non-pregnant controls (group VI, n=4) using flow cytometry. RESULTS: During uncomplicated pregnancy, the CD4(+)CD25(bright) regulatory T cell population decreased with advancing gestational age (group I=3.35+/-0.47, group II=2.91+/-1.44, group III=2.81+/-1.36, group VI=2.52+/-0.71, p=NS). When we compared group IV with group III and V to evaluate the changes of the regulatory T cells with PROM, the CD4(+)CD25(bright) regulatory T cell population was significantly decreased in group IV compared to group III (p=0.001) and group V (p=0.026). CONCLUSION: The present results revealed that the regulatory T cell population increased in early pregnancy but decreased in pregnancies complicated by PROM, indicating that regulatory T cells might be related to the maintenance of pregnancy.
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Texto completo:
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Índice:
WPRIM
Asunto principal:
Rotura Prematura de Membranas Fetales
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Trabajo de Parto
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Antígenos CD4
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Edad Gestacional
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Linfocitos T Reguladores
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Subunidad alfa del Receptor de Interleucina-2
Límite:
Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Yonsei Medical Journal
Año:
2008
Tipo del documento:
Article