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Anti-inflammatory effects of a Houttuynia cordata supercritical extract
Article en En | WPRIM | ID: wpr-79609
Biblioteca responsable: WPRO
ABSTRACT
Anti-inflammatory effects of Houttuynia cordata supercritical extract (HSE) were investigated in a carrageenan-air pouch model. HSE (200 mg/kg, oral) suppressed exudation and albumin leakage, as well as inflammatory cell infiltration. Dexamethasone (2 mg/kg, i.p.) only decreased exudation and cell infiltration, while indomethacin (2 mg/kg, i.p.) reduced exudate volume and albumin content. HSE lowered tumor-necrosis factor (TNF)-alpha and nitric oxide (NO), as well as prostaglandin E2 (PGE2). Dexamethasone only reduced TNF-alpha and NO, while indomethacin decreased TNF-alpha and PGE2. The suppressive activity of HSE on NO and PGE2 production was confirmed in RAW 264.7. These results demonstrate that HSE exerts anti-inflammatory effects by inhibiting both TNF-alpha-NO and cyclooxygenase II-PGE2 pathways.
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Texto completo: 1 Índice: WPRIM Asunto principal: Dexametasona / Medicamentos Herbarios Chinos / Dinoprostona / Transducción de Señal / Carragenina / Indometacina / Análisis de Varianza / Técnicas para Inmunoenzimas / Factor de Necrosis Tumoral alfa / Línea Celular Tumoral Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Journal of Veterinary Science Año: 2010 Tipo del documento: Article
Texto completo: 1 Índice: WPRIM Asunto principal: Dexametasona / Medicamentos Herbarios Chinos / Dinoprostona / Transducción de Señal / Carragenina / Indometacina / Análisis de Varianza / Técnicas para Inmunoenzimas / Factor de Necrosis Tumoral alfa / Línea Celular Tumoral Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Journal of Veterinary Science Año: 2010 Tipo del documento: Article