Anti-inflammatory effects of a Houttuynia cordata supercritical extract
Journal of Veterinary Science
;
: 273-275, 2010.
Artículo
en Inglés
| WPRIM
| ID: wpr-79609
ABSTRACT
Anti-inflammatory effects of Houttuynia cordata supercritical extract (HSE) were investigated in a carrageenan-air pouch model. HSE (200 mg/kg, oral) suppressed exudation and albumin leakage, as well as inflammatory cell infiltration. Dexamethasone (2 mg/kg, i.p.) only decreased exudation and cell infiltration, while indomethacin (2 mg/kg, i.p.) reduced exudate volume and albumin content. HSE lowered tumor-necrosis factor (TNF)-alpha and nitric oxide (NO), as well as prostaglandin E2 (PGE2). Dexamethasone only reduced TNF-alpha and NO, while indomethacin decreased TNF-alpha and PGE2. The suppressive activity of HSE on NO and PGE2 production was confirmed in RAW 264.7. These results demonstrate that HSE exerts anti-inflammatory effects by inhibiting both TNF-alpha-NO and cyclooxygenase II-PGE2 pathways.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Dexametasona
/
Medicamentos Herbarios Chinos
/
Dinoprostona
/
Transducción de Señal
/
Carragenina
/
Indometacina
/
Análisis de Varianza
/
Técnicas para Inmunoenzimas
/
Factor de Necrosis Tumoral alfa
/
Línea Celular Tumoral
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Inglés
Revista:
Journal of Veterinary Science
Año:
2010
Tipo del documento:
Artículo
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