Extremely Elevated International Normalized Ratio of Warfarin in a Patient with CYP2C9*1/*3 and Thyrotoxicosis
Journal of Korean Medical Science
;
: 1317-1319, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-79635
ABSTRACT
A 73-yr-old Korean man with permanent atrial fibrillation visited outpatient clinic with severely increased International Normalized Ratio (INR) values after taking a usual starting dosage of warfarin to prevent thromboembolism. We found out later from his blood tests that he had hyperthyroidism at the time of treatment initiation. His genetic analysis showed CYP2C9*1/*3 and VKORC1+1173TT genotypes. We suspect that both hyperthyroidism and genetic variant would have contributed to his extremely increased INR at the beginning of warfarin therapy. From this case, we learned that pharmacogenetic and thyroid function test might be useful when deciding the starting dosage of warfarin in patients with atrial fibrillation.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fibrilación Atrial
/
Tromboembolia
/
Warfarina
/
Tirotoxicosis
/
Aspirina
/
Cromatografía Líquida de Alta Presión
/
Polimorfismo de Nucleótido Simple
/
Espectrometría de Masas en Tándem
/
Vitamina K Epóxido Reductasas
/
Citocromo P-450 CYP2C9
Límite:
Anciano
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Journal of Korean Medical Science
Año:
2014
Tipo del documento:
Artículo
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