Changes in orexin-A and neuropeptide Y expression in the hypothalamus of the fasted and high-fat diet fed rats
Journal of Veterinary Science
;
: 295-302, 2004.
Artículo
en Inglés
| WPRIM
| ID: wpr-79785
ABSTRACT
This study was aimed to investigate the changes of orexin-A (OXA) and neuropeptide Y (NPY) expression in the hypothalamus of the fasted and high-fat diet fed rats. For the experiments, the male Sprague-Dawley (SD) rats were used as the model of high-fat diet-induced obesity. The mean loss of body weight (MLBW) did not show the linear pattern during the fasting; from 24 h to 84 h of fastings, the MLBW was not significantly changed. The numbers of OXA-immunoreactive (IR) neurons were decreased at 84 h of fasting compared with those in other five fasting subgroups. The NPY immunoreactivities in the arcuate nucleus (ARC) and the suprachiasmatic nucleus (SCN) observed at 84 h of fasting were higher than that observed at 24 h of fasting. The number of OXA-IR neurons of the LHA (lateral hypothalamic area) in the high-fat (HF) diet fed group was more increased than that of the same area in the normal-fat (NF) diet fed group. The NPY immunoreactivities of the ARC and the SCN were higher in HF group than those observed in the same areas of NF group. Based on these results, it is noteworthy that the decrease of the body weight during the fast was not proportionate to the time-course, implicating a possible adaptation of the body for survival against starvation. The HF diet might activate the OXA and the NPY in the LHA to enhance food intake.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Núcleo Supraquiasmático
/
Neuropéptido Y
/
Neuropéptidos
/
Núcleo Arqueado del Hipotálamo
/
Inmunohistoquímica
/
Adaptación Fisiológica
/
Grasas de la Dieta
/
Ayuno
/
Ratas Sprague-Dawley
/
Péptidos y Proteínas de Señalización Intracelular
Límite:
Animales
Idioma:
Inglés
Revista:
Journal of Veterinary Science
Año:
2004
Tipo del documento:
Artículo
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