The effects of hyperbaric oxygen on the hemodynamics and intracranial pressure of patients with severe brain injury: A systematic review of randomized and controlled trials / 中华物理医学与康复杂志

ABSTRACT

Objective@#To systematically evaluate the effects of hyperbaric oxygen on the hemodynamics and intracranial pressure of patients with severe craniocerebral injury (STBI).@*Methods@#Reports of randomized and controlled trials applying hyperbaric oxygen in the treatment of STBI were retrieved from the Pubmed, Cochrane Library, Embase, CBM, CNKI, VIP and Wan Fang databases. Each report found was evaluated by two researchers independently applying pre-defined inclusion and exclusion criteria. The data were extracted and combined and a meta-analysis was performed.@*Results@#Eight trials involving 725 patients were included in the meta-analysis. They combined to demonstrate that intracranial pressure, oxygen uptake and scores on the Glasgow coma scale improved significantly more in the hyperbaric oxygen group than in the control group after between 3 and 10 days of treatment.@*Conclusion@#Hyperbaric oxygen therapy is effective in treating severe craniocerebral injury and it is worthy of clinical application.