Molecular classification of gastric cancer and individualized immunotherapy / 中国肿瘤生物治疗杂志

ABSTRACT

@#Gastric cancer (GC) is one of the malignant tumors with the highest morbidity and mortality in China, and conventional therapies such as surgery, chemotherapy and radiotherapy have limited curative effect on it. GC is highly heterogeneous. With the research on GC deepening into a molecular level and the rapid development of immunotherapy, individualized immunotherapy has become the most promising technology in the field of GC therapy. Several molecular classifications have been put forward in recent years, accurately as well as comprehensively depicting the genomic and molecular characteristics of GC. Moreover, molecular classifications also provided molecular immunological information of GC, which gave implications for the screening of benefit population and treatment decision-making. Based on the several existing GC molecular classifications, this review discussed the guiding significance of molecular classifications on the development and application of GC individualized immunotherapy.