Clinical Efficacy and Serum Metabonomics of Duhuo Xuduan Tang in Treating Lumbar Disc Herniation Due to Liver and Kidney Yin Deficiency / 中国实验方剂学杂志

ABSTRACT

Objective:To observe the efficacy of Duhuo Xuduan Tang in treating patients with liver and kidney Yin-deficiency type of lumbar disc herniation, and explore the changes of metabolomics in serum. Method:Totally 68 cases of non-emergency lumbar disc herniation admitted to the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine from January 2017 to September 2018 were randomly divided into observation group (38 cases) and routine group (30 cases). All of patients in both groups rest in bed after reduction maneuver. The observation group was orally treated with Duhuo Xuduan Tang, 150 mL/time, 2 times/d, and the control group was orally given ibuprofen, 300 mg/time, and vitamin B1, 10 mg/time, 2 times/d. The drugs were administered for 5 days a week and then stopped for 2 days. Both groups were treated continuously for 4 weeks. Before and after treatment, the visual analogue scale (VAS), the Japanese Orthopaedic Association assessment treatment (JOA) score and the clinical efficacy were observed. The serum metabolomics changes of two groups before and after treatment were compared by ultra-high liquid chromatography-mass spectrometry. Result:Compared with before treatment, the VAS scores of two groups were lower, while the JOA scores were increased (PPPβ-cryptoxanthin in serum were increased (PConclusion:Duhuo Xuduan Tang has a clear curative effect in treating lumbar disc herniation with liver and kidney Yin deficiency. The mechanism may be related to the enhancement of energy metabolism, anti-oxidation and anti-inflammation.