Pathogenesis and potential targeted therapy of hemophilic arthropathy / 中华实用儿科临床杂志

ABSTRACT

Hemophilic arthropathy (HA) is one of the most common and typical manifestation in the course of recurrent bleeding episodes in patients with hemophilia.The main pathogenesis are synovial hyperplasia, inflammation and neovascularization, articular cartilage degeneration and bone injury.Considering its pathogenesis, potential targets for disease modifying therapy in HA are iron, inflammation, vascular remodeling, hyper fibrinolysis, bone remodeling and cartilage regeneration.So far, iron chelators, anti-inflammatory therapy, anti-fibrinolytics and bone remodeling agents have demonstrated beneficial effects, predominantly in a preclinical setting.This article reviews the pathogenesis of HA and identifies potential therapeutic targets to provide more therapeutic options for HA.