Analysis of adverse reactions of penicillin combined with chloramphenicol and tetracycline / 中国基层医药

ABSTRACT

Objective@#To investigate the occurrence and characteristics of adverse reactions of penicillin combined with chloramphenicol and tetracycline, so as to provide a reliable basis for the rational clinical application of penicillin, chloramphenicol and tetracycline antibiotics.@*Methods@#From January 2017 to July 2018, 200 cases with adverse reactions of combined use of penicillin, chloramphenicol, tetracycline in Yiwu Central Hospital were chosen.The clinical data of 200 cases of drug adverse reactions report were retrospectively analyzed.The gender distribution, age distribution, dosage, clinical manifestation, adverse reactions involving system, time, unreasonable drug adverse reactions happen were analyzed.@*Results@#Among the 200 adverse reactions, 51.50% cases were male and 48.50% were female, and the difference was not statistically significant(χ2=0.360, P>0.05). The age distribution of 200 cases of adverse reactions was concentrated in people aged less than 14 and more than 60, accounting for 36.50% and 41.00%, respectively.The main routes of administration of 200 adverse reactions were intravenous injection, intramuscular injection and oral administration, accounting for 38.00%, 32.50% and 29.50%, respectively.The clinical manifestations of adverse reactions in 200 cases were mainly anaphylactic shock, bone marrow suppression and dizziness, accounting for 20.00%, 18.50% and 11.50%, respectively.The adverse reactions of 200 cases mainly involved hematopoietic system, nervous system, systemic damage and skin system, accounting for 36.00%, 24.50%, 20.00% and 18.00%, respectively.The adverse reactions of 200 cases occurred within 30 min after medication, accounting for 69.50%.The unreasonable medication of 200 cases of adverse reactions mainly included unreasonable course of medication, unreasonable timing of administration, unreasonable solvent selection, unreasonable dosage and repeated medication.@*Conclusion@#Penicillin, chloramphenicol, tetracycline class of antimicrobial agents combined application has more adverse reactions, the adverse reaction throughout children and the elderly, many involving the hematopoietic system, nervous system, clinical need according to penicillin, chloramphenicol, tetracycline class of antimicrobial agents combined use of the laws and characteristics of adverse reactions in the aftermath of the targeted pharmaceutical intervention, so as to promote clinical rational drug use.