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Expression of Hepatitis C Virus Core Protein in Hepatocytes Does Not Modulate Proliferation or Apoptosis of CD8+ T Cells
Yonsei Medical Journal ; : 827-834, 2005.
Artículo en Inglés | WPRIM | ID: wpr-80418
ABSTRACT
Hepatocytes are the primary targets of the hepatitis C virus (HCV). While immunosuppressive roles of HCV core protein have been found in several studies, it remains uncertain whether core protein expressed in hepatocytes rather than in immune cells affects the CD8+ T cell response. In order to transduce genes selectively into hepatocytes, we developed a baculoviral vector system that enabled primary hepatocytes to express a target epitope for CD8+ T cells, derived from ovalbumin (OVA), with or without HCV core protein. Culture of OVA-specific CD8+ T cells with hepatocytes infected with these baculoviral vectors revealed that core protein has no effect on proliferation or apoptosis of CD8+ T cells. Our results suggest that HCV core protein does not exert its suppressive role on the CD8+ T cell immune response through expression in hepatocytes.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Ovalbúmina / Proteínas del Núcleo Viral / Baculoviridae / Apoptosis / Linfocitos T CD8-positivos / Hepatocitos / Proteínas Fluorescentes Verdes / Proliferación Celular / Vectores Genéticos Límite: Animales Idioma: Inglés Revista: Yonsei Medical Journal Año: 2005 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Ovalbúmina / Proteínas del Núcleo Viral / Baculoviridae / Apoptosis / Linfocitos T CD8-positivos / Hepatocitos / Proteínas Fluorescentes Verdes / Proliferación Celular / Vectores Genéticos Límite: Animales Idioma: Inglés Revista: Yonsei Medical Journal Año: 2005 Tipo del documento: Artículo