The effect of the interaction between apolipoprotein B mRNA editing enzyme-catalytic polypeptidelike 3G and viral infectivity factor on HIV-1 replication / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 221-224, 2019.
Artículo
en Chino
| WPRIM
| ID: wpr-804726
ABSTRACT
Apolipoprotein B mRNA editing enzyme-catalytic polypeptidelike 3G (APOBEC3G), which belongs to the APOBEC family, restricts the replication of HIV-1 through the deminase-dependent and deminase-independent antiviral mechanisms. Viral infectivity factor (Vif), an accessory protein edited by vif gene of HIV-1, promotes APOBEC3G ubiquitination and subsequent degradation by the proteasome result ing in the increased replication of HIV-1. Over the past few years, the discovery of some co-factors such as CBF-β, HDAC6 and MDM2 not only raises our awareness of the interaction between APOBEC3G and Vif but also provides new antiviral targets of HIV-1 in addition. Here we review the structure of APOBEC3G and Vif, and the effect of interference agents on HIV-1 replication by interacting with APOBEC3G and Vif.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Experimental and Clinical Virology
Año:
2019
Tipo del documento:
Artículo
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