Sputum induction method for studying total IgE levels in atopics asthamtic patients / 천식및알레르기
Journal of Asthma, Allergy and Clinical Immunology
;
: 299-307, 1998.
Artículo
en Coreano
| WPRIM
| ID: wpr-80492
ABSTRACT
BACKGROUND:
IgE antibodies have been considered to play an important role in the pathogenesis of atapic asthma. However, there have been only few studies on the role of IgE in airway secretion in the pathogenesis of bronchial asthma. This might be partly due to difficulty in sampling of airway seceretion from asthmatic patients. Recently, sputum induction method by inhalation of nebulized hypertonic saline was developed, and proved to be valid and useful method for obtaining airway secretion from asthmatic patients for studying airway inflammation. OBJECTIVE ANDMETHOD:
To evaluate the usefulness of sputum induction method for studying IgE antibodies in airway secretion from atopic asthmatic patients, total IgE levels in induced sputum from 54 atopic asthmatics were measured by enzyme-linked immunosorbent assay(ELISA) and tried to find an association with sputum eosinophilia.RESULT:
Total IgE levels in induced sputum were significantly higher in atopic asthmatic patients(1.27+82.066 IU/ml) than in controls(0.203+0.291 IUgmP)(p5% of 200 counted leukocytes). There was a significant correlation of total IgE levels between induced sputum and serum in atopic asthmatic patients(r=0.60, p<0.05). Total IgE levels in induced sputum(1.278+ 2.066) were significantly higher than saliva sample(0.504 + 1.111 IU/ml) from atopic asthmatic patients(p<0.05).CONCLUSION:
These results suggest that total IgE levels are increased in the induced sputum of atopic asthmat,ic patients and sputum induction method is a useful tool for studying IgE antibodies in airway secretion from asthmatic patients.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Asma
/
Saliva
/
Esputo
/
Inmunoglobulina E
/
Inhalación
/
Eosinofilia
/
Inflamación
/
Anticuerpos
Límite:
Humanos
Idioma:
Coreano
Revista:
Journal of Asthma, Allergy and Clinical Immunology
Año:
1998
Tipo del documento:
Artículo
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