Research progress in enterovirus D68 / 中华实验和临床病毒学杂志

ABSTRACT

Enterovirus D68 (EV-D68) was first isolated in 1962, and then reported infrequently. As its genetic diversity increased rapidly, the detection rate of EV-D68 has been rising worldwide in recent decade. Since EV-D68 caused the most widespread outbreak in the United States, Canada and Europe in 2014, an increasing number of studies had reported that EV-D68 was associated with severe respiratory diseases and neurological complications, even death. However, the pathogenesis of EV-D68 remains unclear. Moreover, no vaccines or specific antiviral agents are available for prevention and treatment for EV-D68 infection at present. Therefore, continued surveillance and rapid diagnosis of EV-D68 infection will be beneficial to prevent and manage the potential outbreak. This article gives an overview of the biological characteristics, clinical features, and epidemiology of EV-D68.