Etiological characteristics of hand, foot and mouth disease in Dezhou city from 2010 to 2018 / 中华实验和临床病毒学杂志

ABSTRACT

Objective@#To understand the etiological characteristics of hand, foot and mouth diseases (HFMD) in Dezhou city from 2010 to 2018, and to provide laboratory evidence for its prevention and control.@*Methods@#A total of 5 186 fecal specimens were collected from patients with HFMD. Real-time RT-PCR was used to detect enterovirus (EV) and analyze its pathogenic characteristics.@*Results@#From 2010 to 2018, 5 186 samples of HFMD cases were detected in Dezhou, with a total positive rate of 71.75%, including 1 357 cases of EV-A71 (26.17%), 874 cases of CV-A16 (16.85%) and 1 490 cases of other Enteroviruses (28.73%). There were significant differences in the overall detection rate in each month. The peak period of detection rate was from June to August. The dominant virus strains with different types appeared dynamically in different years. EV-A71 was the predominant serotype in severe and aggregated cases. Laboratory confirmed cases were mainly children under 5 years old (96.25%).@*Conclusions@#From 2010 to 2018, the pathogen of HFMD in Dezhou city showed a dynamic change, with obvious seasonal distribution of cases and high incidence of specific population. Etiological surveillance should be strengthened to focus on prevention and control of high-risk population in high-risk season.