Vaginal tubulo-squamous polyp: a clinicopathological analysis of four cases / 中华病理学杂志

ABSTRACT

Objective@#To investigate clinicopathological characteristics of vaginal tubulo-squamous polyp (TSP).@*Methods@#Clinical and pathological data of 4 cases of vaginal TSP diagnosed at Women′s Hospital, School of Medicine, Zhejiang University from 2007 to 2018 were analyzed by hematoxylin-eosin and EnVision two-step immunohistochemical staining technique.@*Results@#The age of the 4 patients ranged from 62 to 71 years, with a mean of 66 years. Histologically, the polyps consisted of an admixture of squamous epithelium and tubules within a fibrous stroma. Immunohistochemically, the cells lining the tubules showed positive staining of prostatic acid phosphatase (PSAP) and/or prostate-specific antigen (PSA) in all 4 cases. Available follow-up in 3 patients for 4 to 6 months (mean of 5.3 months) showed no tumor recurrence.@*Conclusion@#TSP is an under-recognized benign vaginal polypoid disease that may develop from paraurethral Skene glands.