A Case of Effective Post-centrifugal Plasma Filtration for L-asparaginase-induced Severe Hyperlipidemia / 대한수혈학회지
Korean Journal of Blood Transfusion
;
: 269-274, 2007.
Artículo
en Coreano
| WPRIM
| ID: wpr-80661
ABSTRACT
Hyperlipidemia has been reported in children with acute lymphoblastic leukemiawho have been treated with L-asparaginase alone or in combination with a steroid. Hyperlipidemia caused by L-asparaginase is usuallyreversible after drug discontinuation, and is rarely associated with severe complications. However, the risk of acute pancreatitis is increased if there is a large increase in triglyceride levels. Prompt correction of hyperlipidemia should be considered to prevent this severe complication. We report a case of successful correction of L-asparaginase-associated severe relapsed hyperlipidemia using post-centrifugal plasma filtration (PCPF), a type of selective plasmapheresis. After 3 sessions of PCPF, the serum concentrations of lipids were markedly reduced. The serum concentration for triglyceridewas reduced to 475 mg/dL from 6,298 mg/dL, the total cholesterol level was reduced to 176 mg/dL from 946 mg/dL, and the level of low-density lipoprotein was reduced to 4 mg/dL from 403 mg/dL. One month later, as determined at the outpatient clinic, the lipid levels were normalized. PCPF was effective for clearing severely increased plasma lipids.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pancreatitis
/
Plasma
/
Triglicéridos
/
Hipertrigliceridemia
/
Colesterol
/
Plasmaféresis
/
Filtración
/
Instituciones de Atención Ambulatoria
/
Hiperlipidemias
/
Lipoproteínas
Límite:
Niño
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Blood Transfusion
Año:
2007
Tipo del documento:
Artículo
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