Research progress of beta3-adrenergic receptor in heart / 中国小儿急救医学

ABSTRACT

The expression of beta3-adrenergic receptor(β3-AR) is very low in the physiological state of the heart, but increases in the pathological state of heart failure.Due to the negative inotropic effect when stimulating β3-AR, the early researchers believed that the increase of β3-AR in the pathological state would aggravate the cardiac function, but the later researches of beta3-AR on heart failure found a contrary conclusion.More and more evidence suggests that beta3-AR may play a useful role in the cardiovascular system, which making beta3-AR to be a new target for the treatment of cardiovascular disease.This article reviewed the progress of the above researches.