Risk factors of bacterial nosocomial infection after pediatric liver transplantation / 中华儿科杂志

ABSTRACT

Objective@#To analyze the risk factors of nosocomial infection after liver transplantation in children, so as to provide scientific evidence for the prevention and control of nosocomial infection.@*Method@#Clinical data of 223 pediatric patients undergoing liver transplantation between January 2014 and December 2015 were analyzed retrospectively. Univariate and multivariate analyses were carried out to investigate the risk factors of infection after transplantation.@*Result@#Totally 51 children were infected among the 223 patients, the infection rate was 22.86%(51/223). Among the 74 cases with infection, 38 were infected with the blood (included peripherally inserted central catheters) accounting for 51.35 %; and surgical site infection accounted for 21.62%, the respiratory tract infections accounted for 18.92% and the other infections accounted for 8.11%. Totally 74 strains of infectious pathogens were found in 51 cases of infected patients, including Gram-negative bacteria accounting for 48.65%, Gram-positive bacteria accounting for 44.59% and the fungus accounting for 6.76%. According to a variety of survey factors, univariate analysis showed factors of hospitalization time, hospitalization time before surgery, surgical duration, and reoperation had statistically significant association with nosocomial infection(P<0.05). Logistic regression analysis showed that hospitalization time before surgery, surgical duration, reoperation and blood loss per unit weight were independent risk factors for nosocomial infection after pediatric liver transplantation.@*Conclusion@#There are a variety of risk factors for the postoperative infections after liver transplantation in children. It is necessary to take into account the surgery factor, medical staff factor and hospital management factor. Management strengthening of these factors is necessary to reduce the infection rate.