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A Novel Pancreatic Imaging Window for Stabilized Longitudinal In Vivo Observation of Pancreatic Islets in Murine Model
Diabetes & Metabolism Journal ; : 193-198, 2020.
Artículo en Inglés | WPRIM | ID: wpr-811136
ABSTRACT
Longitudinal imaging of murine pancreas is technically challenging due to the mechanical softness of the tissue influenced by peristalsis. Here, we report a novel pancreatic imaging window for long-term stabilized cellular-level observation of the islets in the pancreas in vivo. By spatially separating the pancreas from the bowel movement and physiologic respiration with a metal plate integrated in the imaging window, we successfully tracked the pancreatic islets up to three weeks and visualized the dumbbell-shape transformation from the single islet. This window can be a useful tool for long-term cellular-level visualization of the microstructure in the pancreas.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Páncreas / Peristaltismo / Respiración / Islotes Pancreáticos / Microscopía Intravital Límite: Animales Idioma: Inglés Revista: Diabetes & Metabolism Journal Año: 2020 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Páncreas / Peristaltismo / Respiración / Islotes Pancreáticos / Microscopía Intravital Límite: Animales Idioma: Inglés Revista: Diabetes & Metabolism Journal Año: 2020 Tipo del documento: Artículo