Paget's Disease of Bone Affecting Peripheral Limb: Difficulties in Diagnosis: A Case Report
Journal of Bone Metabolism
;
: 71-75, 2020.
Artículo
en Inglés
| WPRIM
| ID: wpr-811182
ABSTRACT
In terms of management of Paget's disease of bone (PDB), early diagnosis and proper management achieving remission is essential with lifelong specialist follow-up. We present the case of a 40-year-old woman with PDB affecting mainly the distal extremities (ankle and wrist). The patient visited our hospital in 2012 with heel pain. Plain radiography revealed osteoporosis, and a bone scan revealed hot uptake. Initial laboratory investigations showed normal serum calcium, 25-hydroxy-vitamin D, and parathyroid hormone levels; however, osteocalcin, C-terminal telopeptide of type I collagen, and bone alkaline phosphatase levels were elevated. A bone mineral density scan showed T- and Z-scores of −2.5 and −2.7, respectively, and bisphosphonate treatment was initiated. Biopsy performed on the calcaneal lateral wall revealed inconclusive findings. Follow-up biopsy on the left distal radius was performed 7 years later to investigate wrist pain, and this examination led to a final diagnosis as PDB. We suggest inconclusive biopsy result during the early phase of PDB and highly recommend follow-up evaluation in osteoporosis with atypical behavior.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Osteítis Deformante
/
Osteoporosis
/
Hormona Paratiroidea
/
Radio (Anatomía)
/
Especialización
/
Muñeca
/
Biopsia
/
Talón
/
Radiografía
/
Densidad Ósea
Tipo de estudio:
Estudio diagnóstico
/
Estudio observacional
/
Estudio pronóstico
/
Estudio de tamizaje
Límite:
Adulto
/
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Journal of Bone Metabolism
Año:
2020
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS