Design, synthesis and biological evaluation of five-membered heterocyclopyrimidines as MTH1 inhibitors / 中国药科大学学报
Journal of China Pharmaceutical University
;
(6): 407-412, 2018.
Artículo
en Chino
| WPRIM
| ID: wpr-811737
ABSTRACT
@#Based on the reported inhibitors TH287, 17 five-membered heterocyclopyrimidine derivatives were designed and synthesized by cyclization, scaffold hopping, bioisosterism and molecular docking technology. The bioassays determined by malachite green method demonstrated that the target compounds displayed good inhibitory activity against MTH1. Among them, the IC50 value of 7 compounds was less than 1 μmol/L, suggesting that these compounds may be candidates for further investigation.
Texto completo:
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Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Journal of China Pharmaceutical University
Año:
2018
Tipo del documento:
Artículo
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