Three new anthraquinone derivatives isolated from Symplocos racemosa and their antibiofilm activity / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 944-949, 2017.
Artículo
en Inglés
| WPRIM
| ID: wpr-812037
ABSTRACT
Three new alkyl substituted anthraquinone derivatives, trivially named as symploquinones A-C (Compounds 1-3) were isolated from Symplocos racemosa. The structures of these compounds were determined on the basis of extensive spectroscopic analyses (UV, IR, Mass, H- and C-NMR, and two-dimensional (2D) NMR techniques). The resulting data were also compared with the reported literature. These compounds were then subjected to antibacterial or antibiofilm testing. Compounds 1 and 3 exhibited good antibacterial activity in the concentration range of 160-83 μg·mL against Streptococcus mutans, methicillin resistant Staphylococcus aureus and Proteus mirabilis. Both compounds were further screened for anti-biofilm activity, which revealed promising activities at sub-MIC concentrations. None of the compounds were found to be active against Klebsiella pneumoniae.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Fisiología
/
Proteus mirabilis
/
Espectrofotometría Infrarroja
/
Espectrometría de Masas
/
Streptococcus mutans
/
Espectroscopía de Resonancia Magnética
/
Pruebas de Sensibilidad Microbiana
/
Química
/
Antraquinonas
Idioma:
Inglés
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Año:
2017
Tipo del documento:
Artículo
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