Protosappanin A exerts anti-neuroinflammatory effect by inhibiting JAK2-STAT3 pathway in lipopolysaccharide-induced BV2 microglia / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 674-679, 2017.
Article
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| WPRIM
| ID: wpr-812069
Biblioteca responsable:
WPRO
ABSTRACT
Microglial activation and resultant neuroinflammatory response are implicated in various brain diseases including Alzheimer's disease and Parkinson's disease. Treatment with anti-neuroinflammatory agents could provide therapeutic benefits for such disorders. Protosappanin A (PTA) is a major bioactive ingredient isolated from Caesalpinia sappan L.. In this work, the anti-neuroinflammatory effects of PTA on LPS-stimulated BV2 cells were investigated and the underlying mechanisms were explored. Results showed that PTA significantly inhibited the production of TNF-α and IL-1β in LPS-activated BV2 microglia. Moreover, the mRNA expressions of IL-6, IL-1β, and MCP-1 were reduced by PTA in a dose-dependent manner. Furthermore, PTA suppressed JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3, as well as STAT3 nuclear translocation against LPS treatment. These observations suggested a novel role for PTA in regulating LPS-induced neuroinflammatory injuries.
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WPRIM
Asunto principal:
Farmacología
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Fenoles
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Transducción de Señal
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Lipopolisacáridos
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Factor de Necrosis Tumoral alfa
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Microglía
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Quimioterapia
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Alergia e Inmunología
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Factor de Transcripción STAT3
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Interleucina-1beta
Límite:
Animals
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Humans
Idioma:
En
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Año:
2017
Tipo del documento:
Article