Antibacterial steroidal alkaloids from Holarrhena antidysenteriaca / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 540-545, 2017.
Artículo
en Inglés
| WPRIM
| ID: wpr-812083
ABSTRACT
Two new steroidal alkaloids, isoconkuressine and N-formylconessimine, together with 6 known steroidal alkaloids including conkuressine, conessine, isoconessimine, conimine, conarrhimine, and funtudienine, were isolated from the seeds of Holarrhena antidysenteriaca Wall.ex A.DC. Their intrinsic antibacterial activities and synergistic effects with penicillin and vancomycin were analyzed in methicillin sensitive staphylococcus aureus (MSSA) and methicillin resistant staphylococcus aureus (MRSA). Two of the steroidal alkaloids including one new compound (N-formylconessimine) showed potential antibacterial activity and possessed synergistic effects with penicillin and vancomycin, respectively.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Staphylococcus aureus
/
Extractos Vegetales
/
Pruebas de Sensibilidad Microbiana
/
Química
/
Holarrhena
/
Alcaloides
/
Staphylococcus aureus Resistente a Meticilina
/
Antibacterianos
Idioma:
Inglés
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Año:
2017
Tipo del documento:
Artículo
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