Synthesis and cytotoxicity of longistylin C derivatives / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 311-315, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-812140
ABSTRACT
The present study was designed to identify potent anti-tumor compounds from a series of new longistylin C derivatives. Ten longistylin C derivatives were synthesized and their structures were confirmed by (1)H NMR, MS, and elemental analyses. Their cytotoxicity in vitro against three human cancer cell lines (A549, HepG2, and MCF-7) were evaluated by the MTT assay. Among these compounds, DT-6 and DT-9 displayed much better cytotoxicity against A549, HepG2, and MCF-7 cells, DT-1 exhibited selective cytotoxicity against HepG2, and the structure-activity relationships were investigated. In conclusion, Compounds DT-6 and DT-9 may serve as potential lead compounds for the discovery of new anti-cancer drugs.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Relación Estructura-Actividad
/
Ensayos de Selección de Medicamentos Antitumorales
/
Línea Celular Tumoral
/
Antineoplásicos
Límite:
Humanos
Idioma:
Inglés
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Año:
2015
Tipo del documento:
Artículo
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