Triterpenes from the stem bark of Mitragyna diversifolia and their cytotoxic activity / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 628-631, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-812223
ABSTRACT
AIM@#To study the chemical constituents and bioactivity of the stem bark of Mitragyna diversifolia.@*METHOD@#Compounds were isolated by various chromatographic methods. Their structures were elucidated on the basis of spectroscopic techniques (IR, UV, MS, and NMR), and they were evaluated for their cytotoxic activities by the MTT method.@*RESULTS@#Eight triterpenes were isolated and identified as 3α, 6β, 19α-trihydroxy-urs-12-en-28-oic acid (1), 3β, 6β, 19α-trihydroxy-urs-12-en-28-oic acid (2), 3-oxo-6β-19α-dihydroxy-urs-12-en-28-oic acid (3), 3β, 6β, 19α-trihydroxy-urs-12-en-24, 28-dioic acid 24-methyl ester (4), 3β, 6β, 19α, 24-tetrahydroxy-urs-12-en-28-oic acid (5), rotundic acid (6), 23-nor-24-exomethylene- 3β, 6β, 19α-trihydroxy-urs-12-en-28-oic acid (7), and pololic acid (8), respectively. All of the isolates were tested against two human tumor cell lines, MCF-7 (breast) and HT-29 (colon).@*CONCLUSION@#Compound 1 was a new triterpene. Compounds 5 - 7 exhibited potent inhibitory effects on the growth of MCF-7 and HT-29 cells, and the others showed no cytotoxicity.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Triterpenos
/
Extractos Vegetales
/
Estructura Molecular
/
Química
/
Tallos de la Planta
/
Células HT29
/
Corteza de la Planta
/
Mitragyna
/
Usos Terapéuticos
Límite:
Humanos
Idioma:
Inglés
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Año:
2014
Tipo del documento:
Artículo
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