A new bufadienolide with cytotoxic activity from the Chinese traditional drug Ch'an Su / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 623-627, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-812224
ABSTRACT
AIM@#To study the bufadienolides in the Chinese traditional drug "Ch'an Su" and their cytotoxic activity.@*METHOD@#Various chromatographic techniques were used to isolate the constituents, and their structures were elucidated through physical and spectroscopic data.@*RESULTS@#Twenty compounds were isolated, and eighteen were evaluated in vitro for their cytotoxic activity against A-549 and K-562 cells.@*CONCLUSION@#Compound 1 (bufalin 3β-acrylic ester) was a new bufadienolide and exhibited the most potent activity against the two tumor cell lines with IC50 values of 7.16 and 6.83 nmol · L(-1). The relationships between structure and activity are discussed.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Relación Estructura-Actividad
/
Productos Biológicos
/
Bufanólidos
/
Estructura Molecular
/
Química
/
Células K562
/
Concentración 50 Inhibidora
/
Usos Terapéuticos
/
Quimioterapia
Tipo de estudio:
Estudio diagnóstico
Límite:
Humanos
Idioma:
Inglés
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Año:
2014
Tipo del documento:
Artículo
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