New 9, 19-cycloartane triterpenoid from the root of Cimicifuga foetida / 中国天然药物

ABSTRACT

AIM@#To study the 9, 19-cycloartane triterpenes from the roots of Cimicifuga foetida.@*METHOD@#Chromatographic separations by silica gel, C18 reversed phase silica gel, and high-performance liquid chromatography (HPLC) were used. All of the structures were elucidated on the basis of spectroscopic analysis and chemical methods.@*RESULTS@#Five 9, 19-cycloartane triterpenes, (3β, 12β, 15α, 24R)-12, 2'-diacetoxy-24, 25-epoxy-15-hydroxy-16, 23-dione-3-O-α-L-arabinopyranoside (1), actein (2), 23-epi-26-deoxyactein (3), asiaticoside B (4), and 12β-hydroxycimigenol (5) were isolated from the roots of Cimicifuga foetida.@*CONCLUSION@#Compound 1 is a new triterpene with two acetoxy groups at C-2' and C-12.