A new quinoline alkaloid from the roots of Dictamnus angustifolius / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 222-224, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-812282
ABSTRACT
AIM@#To investigate the quinoline alkaloids from the roots of Dictamnus angustifolius G.Don ex Sweet (Rutaceae).@*METHOD@#The quinoline alkaloids were isolated by various column chromatographic methods and their structures were elucidated on the basis of spectral analysis.@*RESULTS@#A new quinoline alkaloid, 5-methoxylrobustine (1), along with five known quinoline alkaloids were obtained, and their structures were identified as dictamnine (2), robustine (3), isopteleine (4), γ-fagarine (5), and skimmianine (6). Cytotoxicity testing of these alkaloids showed that all of them had weak cytotoxic activities against human breast cancer cells (MCF7).@*CONCLUSION@#Compound 1 is a new quinoline alkaloid. Alkaloid 3 showed stronger anti-proliferation effect than the other alkaloids.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Quinolinas
/
Neoplasias de la Mama
/
Extractos Vegetales
/
Estructura Molecular
/
Química
/
Raíces de Plantas
/
Dictamnus
/
Línea Celular Tumoral
/
Usos Terapéuticos
Límite:
Humanos
Idioma:
Inglés
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Año:
2014
Tipo del documento:
Artículo
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