Chemical constituents of Euphorbia tibetica and their biological activities / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 38-42, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-812311
ABSTRACT
AIM@#To investigate the chemical constituents and their biological activities of the aerial parts of Euphorbia tibetica.@*METHOD@#Compounds were isolated and purified by various chromatographic methods, and their structures were elucidated through the use of extensive spectroscopic techniques including 2D-NMR, the structures of compounds 5 and 6 were confirmed by single-crystal X-ray crystallography. Bioactivities of all the isolated compounds were evaluated by the MTT method on A549 and anti-angiogenesis assay.@*RESULTS@#One new compound, methyl 4-epi-shikimate-3-O-gallate (1), together with twenty-three known constituents (2-24) were isolated from the aerial parts of E. tibetica.@*CONCLUSION@#Compound 1 is new, and the other compounds were isolated from this plant for the first time. Compounds 5-7, 9, 11, 17, 18 and 20 exhibited inhibitory effects on the growth of human lung cancer cell A549 and compounds 5, 7, 12, 13, 17 and 19 showed anti-angiogenic effects in a zebrafish model.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Pez Cebra
/
Medicamentos Herbarios Chinos
/
Estructura Molecular
/
Línea Celular
/
Química
/
Inhibidores de la Angiogénesis
/
Euphorbia
/
Proliferación Celular
/
Inhibidores de Crecimiento
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Año:
2014
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS